Ceftiofur Crystalline Free Acid

What is ceftiofur crystalline free acid?

Ceftiofur crystalline free acid (Excede®) is a third-generation cephalosporin antibiotic used to treat certain bacterial infections in horses, cattle, swine, rabbits, birds, and other animals. There are various formulations of ceftiofur (HCl, sodium, CFA).

It is used off label (extra label) in animals other than horses, cattle, and swine. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How do I give my pet ceftiofur crystalline free acid?

Ceftiofur crystalline free acid comes in an injectable form.

• Injections are given intramuscularly (into the muscle) or subcutaneously (under the skin).
• Shake well before using.
• Dispose of used needles in a designated sharps container.
• Give this medication exactly as prescribed and directed by your veterinarian.
• Sudden death may occur if accidentally given intravenously (into a blood vessel).

This medication should take effect within a few hours; however, outward effects may not be immediately noticeable. 

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Ceftiofur crystalline free acid may cause the following side effects:

• Diarrhea, upset stomach
• Loss of appetite
• Pain, mild swelling at injection site

Serious adverse reactions may occur. If any of the following signs develop, stop giving ceftiofur crystalline free acid and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
• Severe diarrhea

Sudden death may occur if given into a vein or artery – give this medication exactly as directed. Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, though effects may last longer in pets with kidney and/or liver disease.

Are there any risk factors for this medication?

DO NOT USE this medication in:

• Animals who are allergic to any component of the medication, other cephalosporins, or other similar drugs (e.g. penicillin)

USE WITH CAUTION in:

• Animals with kidney disease 

Are there any drug interactions I should be aware of?

Several medications should be used with caution when given with ceftiofur crystalline free acid, including:

• Aminoglycosides (e.g., amikacin, gentamicin)
• Probenecid
• Potentially nephrotoxic drugs (e.g., amphotericin B, furosemide)

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects. 
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.

How do I store ceftiofur crystalline free acid?

• Store at room temperature of 20°C to 25°C (68°F-77°F). 
• Discard product 12 weeks after first dose is removed.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.